Salmon DNA PDRN Injection — What Is It? | Kind Global Clinic
Salmon DNA injections explained — PDRN vs PN, from ₩169,000 first-visit 2cc · Book consultation
Private consultation suite at Kind Global Clinic Myeongdong where a co-director explains what salmon DNA PDRN injections are before any session
Regenerative Skin Booster · Myeongdong 6F

Salmon DNA PDRN Injection — What It Is, Explained by Physicians

Salmon DNA injections are purified polynucleotide fragments that signal dermal repair — a 2-4 week interval course, 24-48h of injection marks, from ₩149,000 (≈ $106) per session. This guide explains what PDRN is, what PN is, and which one is actually in the vial at a Seoul clinic.

DNA
Active ingredient — purified salmon polynucleotides
3
Sessions in a standard course, 2-4 weeks apart
24-48h
Visible injection marks, then normal skin
Quick Answer

What is a salmon DNA PDRN injection?

Purified DNA fragments from salmon, injected into the dermis to signal repair — that is what a salmon DNA PDRN injection is. The class covers two ingredients, PDRN and the more refined PN used in Rejuran, offered from ₩149,000 (≈ $106) per session at Kind Global Clinic Myeongdong.

A salmon DNA PDRN injection is a regenerative skin treatment: fragments of deoxyribonucleic acid, extracted and purified from salmon, are placed into the skin in a grid of micro-injections, where they act as a biological signal — supporting fibroblast activity, tissue repair and elasticity — rather than as a filler that adds volume. The search term bundles two distinct ingredients, and the distinction is the single most useful thing this page can give you. PDRN (polydeoxyribonucleotide) is the shorter-fragment form with a long history in wound-healing and regenerative medicine. PN (polynucleotide) is a higher-molecular-weight, further-refined fraction — and PN, not PDRN, is what Rejuran, the Korean-manufactured product behind the 'salmon DNA' trend, actually contains.

Why salmon? Salmon DNA is unusually compatible with human tissue, provokes minimal immune response after purification, and is harvested from a controlled, traceable source — which is why both PDRN and PN products built on it have accumulated a substantial clinical literature. At Kind Global Clinic Myeongdong, both forms exist on the published menu at fixed KRW rates: PN sessions from ₩149,000 (≈ $106) for the HB 1cc tier and ₩179,000 (≈ $128) for Healer 2cc, and a targeted PDRN injection at ₩100,000 (≈ $71) for 1cc in acne and scar care. Which fragment class fits your skin is a physician judgment made in a 15-20 minute co-director consultation — not a menu order, and never a substitute term for the other.

Who is this for?

Who this salmon DNA injection guide is for

For

  • ✓ Anyone who searched 'salmon dna pdrn injection what is it' and wants the ingredient, mechanism and evidence explained before any clinic conversation
  • ✓ Patients offered 'salmon DNA facials' abroad who want to know whether the vial holds PDRN, PN, or a topical serum that never reaches the dermis
  • ✓ Under-eye fine lines, post-acne texture, enlarged pores and thin, crepey skin — the profiles polynucleotide injections serve in published studies
  • ✓ Travelers comparing Seoul's injectable PN pricing — from ₩149,000 (≈ $106) per session — against quotes at home
  • ✓ Skeptics who want the honest limits: what DNA injections do, what they cannot do, and how many sessions the literature actually supports

Not for

  • ✗ Anyone seeking instant volume — DNA fragments signal repair over weeks; they do not lift cheeks or fill deep folds the way HA filler does
  • ✗ One-session miracle expectations — the published evidence pattern is progressive improvement across a 3-session course
  • ✗ Active skin infection, certain autoimmune conditions or pregnancy — screened out in consultation before any injection
  • ✗ Patients unwilling to accept 24-48 hours of visible micro-injection marks after each session
How it works

How a salmon DNA injection session actually works, step by step

  1. 1

    Step 1 — Ingredient-level consultation (15-20 minutes)

    A co-director examines your skin and explains which fragment class fits: PN (Rejuran) for full-face texture, elasticity and under-eye work, or a targeted 1cc PDRN injection in acne-scar care. You leave the consultation knowing the exact product name, volume and published price before anything is booked.

  2. 2

    Step 2 — Product and tier selection from the published menu

    PN tiers are fixed and public: Rejuran HB 1cc ₩149,000 (≈ $106), Healer 2cc ₩179,000 (≈ $128), Eye 1cc ₩119,000 (≈ $85), 4cc Signature ₩249,000 (≈ $178); targeted PDRN 1cc runs ₩100,000 (≈ $71). Eligible first visits take a 2cc PN rate of ₩169,000 (≈ $121).

  3. 3

    Step 3 — Numbing and vial verification (20-30 minutes)

    Topical anesthetic sits for 20-30 minutes while the sealed vial is opened in front of you, with product name and lot recorded on your chart — the practical answer to the 'what is actually in a salmon DNA injection' question is written into your own record.

  4. 4

    Step 4 — Micro-depot injection by a co-director (10-20 minutes)

    The physician places the DNA fragments in a grid of shallow micro-injections across the mapped zones — a full-face 2cc session typically takes 10-15 minutes. The under-eye zone uses an adapted technique for its thin skin, and Aeronox nitrous-oxide analgesia is available for sensitive patients.

  5. 5

    Step 5 — The biology does the slow work

    Over the following 2-4 weeks the fragments are metabolized while signaling fibroblast activity and dermal repair — which is why sessions are spaced 2-4 weeks apart and why a standard course is 3 sessions rather than one. There is nothing to activate, boost or maintain at home beyond SPF and normal skincare.

  6. 6

    Step 6 — Photo review between sessions

    Daylight photos on the clinic messenger thread get a physician review at no added cost, and the same co-director calibrates session two and three against your baseline set — dose, zones and interval adjusted to how your skin answered session one.

What to expect

What salmon DNA injections do, on the honest timeline

Day 0Micro-injection grid delivered — visible points and small bumps for 24-48 hours are the expected look, not a complication
Day 2-7Marks resolve; early hydration and surface smoothness are typically the first changes patients notice
Week 2-4Interval to session two — dermal repair signaling builds beneath the surface while photos start catching texture change
Week 8-12Course-completion window — published polynucleotide studies document elasticity and wrinkle improvement accumulating across this period
Month 6Results hold for most completed courses; baseline photo comparison decides whether maintenance is worth booking
Month 6-12Typical maintenance window — a single session at the published per-session rate, not a repurchase of the full course
Comparison

PDRN vs PN vs HA — what is actually in the syringe

AxisPDRN (polydeoxyribonucleotide)PN (polynucleotide — Rejuran)HA skin booster
What it isShorter salmon-DNA fragments with a long wound-healing literatureHigher-molecular-weight, further-refined salmon-DNA fractionCross-linked or free hyaluronic acid — a sugar, not DNA
Primary actionRepair signaling — studied via receptor pathways supporting tissue regenerationRepair signaling plus a physical scaffold effect from longer chainsWater binding — hydration and surface glow
Typical role at KindTargeted 1cc injections in acne and scar careFull-face, under-eye, lip and neck regenerative coursesHydration component, including the PN+HA hybrid Rejuran HB
Price₩100,000 (≈ $71) per 1ccFrom ₩149,000 (≈ $106) (HB 1cc) to ₩249,000 (≈ $178) (4cc Signature)Product-dependent — quoted in consultation
Result curveBuilds with repeated targeted sessionsBuilds across a 3-session course, 2-4 weeks apartReads fastest, first 1-2 weeks
Downtime24-48h injection marks24-48h injection marks24-48h injection marks
Injector at KindCo-director, zero delegationCo-director, zero delegationCo-director, zero delegation

The terms are not interchangeable, and a clinic that uses them interchangeably is telling you something. Rejuran contains PN — if a menu sells 'Rejuran PDRN', the label is wrong on the ingredient level. Both fragment classes are legitimately on the published menu at Kind Global Clinic Myeongdong for different jobs, and the full clinic-wide figures sit on the published price list.

Pricing

Salmon DNA injections — the published Seoul menu

Rejuran Healer

2cc
₩179,000 ₩214,000
    Book Consultation

    Rejuran HB

    1cc
    ₩149,000 ₩178,000
      Book Consultation

      Lip Rejuran HB

      1cc
      ₩219,000 ₩262,000
        Book Consultation

        Rejuran Eye

        1cc
        ₩119,000 ₩142,000
          Book Consultation

          Kind Premium Rejuran (Signature)

          4cc
          ₩249,000 ₩298,000
            Book Consultation

            Published polynucleotide (PN) tiers at Kind Global Clinic Myeongdong: Rejuran Healer 2cc ₩179,000 (list ₩179,000) · Rejuran HB 1cc ₩149,000 · Rejuran Eye 1cc ₩119,000 · Kind Premium Rejuran Signature 4cc ₩249,000 · first-visit 2cc ₩169,000. Targeted PDRN injection in acne-scar care: ₩100,000 per 1cc. Every figure includes consultation, vial verification on your chart, the co-director-performed session and messenger follow-up — same KRW for international and Korean patients, nothing invoiced after the session.

            October 2026 · First Visit

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            Your doctors

            The physicians who explain it are the ones who inject it

            Dr. Lee Wonjin, Co-Director of Kind Global Clinic Myeongdong

            Dr. Lee Wonjin

            Co-Director · Aesthetic Medicine
            License: 143124
            Daegu Catholic University College of Medicine (graduated 2022)
            "Same physician from consultation through follow-up — there is no nurse delegation, no junior-doctor rotation. Cartridge serial and line counts are recorded on every patient's chart."
            Dr. Lee Kangin, Co-Director of Kind Global Clinic Myeongdong

            Dr. Lee Kangin

            Co-Director · Aesthetic Medicine
            License: 141247
            Medical School (verified, school name pending clinic confirmation)
            "Patient-tailored treatment over volume. Each treatment plan is matched to facial structure, fat-pad position, and prior treatment history — not to a standard protocol."

            Medically reviewed by Dr. Lee Wonjin, Kind Global Clinic.

            Evidence

            The evidence behind salmon DNA injections — PDRN and PN in the literature

            1. Pharmacological Activity and Clinical Use of PDRN
              Front Pharmacol (2017) — DOI: 10.3389/fphar.2017.00224 — PMID: 28491036

              The reference pharmacology review of PDRN: salmon-derived polydeoxyribonucleotide acts through adenosine A2A receptor stimulation and the salvage pathway, with documented clinical use in tissue repair and wound healing — the mechanistic backbone of the entire 'salmon DNA injection' category.

            2. Polynucleotides and polydeoxyribonucleotides in dermatology — A narrative review
              J Cutan Aesthet Surg (2025) — DOI: 10.25259/jcas_65_2025

              Narrative review mapping the PN-versus-PDRN distinction this page is built on: fragment length, purification and clinical roles of both salmon-DNA classes in aesthetic practice, including the Korean-manufactured PN products such as Rejuran that anchor the injectable category.

            3. Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients
              Dermatol Ther (2015) — DOI: 10.1111/dth.12299 — PMID: 26814448

              Early Korean clinical report on long-chain polynucleotide injections for skin rejuvenation, documenting efficacy and the tolerability profile in Korean patients — part of the Seoul-centered evidence base that preceded the treatment's international 'salmon sperm facial' fame.

            Recovery

            After a salmon DNA injection — what actually happens

            WhenWhatDoDon't
            Day 0 (session day)A visible grid of micro-injection points with small raised bumps at each depot — expected, and the reason sessions are scheduled around photos, not the other way roundCold pack briefly if warm · gentle cleanser only tonight · sleep slightly elevatedMakeup over open points today · sauna, jjimjilbang, hot yoga or alcohol for 48 hours · pressing or massaging the grid
            Day 1-2Bumps flatten and points fade; the under-eye zone can hold faint marks a day longer than cheeks, and minor bruising there is possibleMakeup from 24 hours once points close · moisturizer and SPF daily · fly whenever scheduled — no flight restriction appliesExfoliating acids, retinoids or home devices on treated skin this week
            Week 1-4Skin looks normal; hydration and smoothness read first while repair signaling builds toward session two at the 2-4 week intervalSend daylight photos on the clinic messenger thread for the included physician review · book session twoJudge a repair-signal treatment on week-one photos — the published curve builds across the course
            Week 8-12 and beyondCourse evaluation against your baseline set — texture, fine lines and elasticity are where published studies locate the changeKeep the photo set for the month-6 comparison · plan any maintenance session against evidence, not habitChase extra sessions inside the course window — more DNA sooner is not a documented shortcut
            Frequently asked

            Salmon DNA PDRN injections — the questions people actually search

            What is a salmon DNA PDRN injection in simple terms?
            Purified DNA fragments from salmon, injected into the skin in a grid of tiny depots, where they signal your own repair processes — that is the whole idea. Unlike a filler, nothing is added for volume; unlike a laser, nothing is heated or removed. The fragments support fibroblast activity, elasticity and tissue repair over the following weeks, which is why results build across a 3-session course spaced 2-4 weeks apart rather than appearing overnight. At Kind Global Clinic Myeongdong the treatment is delivered by a licensed co-director in a private 1:1 suite, with the sealed vial opened in front of you and recorded on your chart before injection.
            What is the difference between PDRN and PN?
            Fragment length and refinement — and the difference decides what is in your vial.
            AxisPDRNPN
            Full namePolydeoxyribonucleotidePolynucleotide
            Fragment sizeShorter chainsLonger, higher-molecular-weight chains
            Track recordWound-healing and regenerative medicine literatureAesthetic dermal repair — the Rejuran category
            Role at KindTargeted 1cc injections, ₩100,000 (≈ $71)Full-face and under-eye courses from ₩149,000 (≈ $106)
            Both derive from salmon DNA, both signal repair — but Rejuran contains PN, and a menu that labels it PDRN is wrong at the ingredient level.
            Is Rejuran a PDRN injection?
            No — Rejuran contains PN (polynucleotide), a higher-molecular-weight, further-refined salmon-DNA fraction, not PDRN. The confusion is understandable because both ingredients come from salmon DNA and both signal tissue repair, and international media use 'salmon sperm facial' and 'PDRN facial' for everything in the category. But the Korean manufacturer classifies Rejuran Healer as a PN product, and the distinction has practical weight: fragment length affects how the product behaves in the dermis and how it is dosed across a course. A clinic that cannot tell you which fragment class it is injecting has answered your due-diligence question already.
            What do salmon DNA injections actually do for skin?
            They signal repair on 3 documented fronts: fibroblast activity that supports collagen and elastin, tissue regeneration studied through adenosine A2A receptor pathways, and dermal hydration from the scaffold the longer PN chains form. In published clinical work that translates to improved skin texture, fine lines — particularly under the eyes, where a Korean randomized split-face trial tested PN directly — elasticity and post-acne surface quality. What they do not do is add volume, lift a jawline or erase deep folds; a repair signal is not a filler. The honest framing: gradual, cumulative quality-of-skin change across an 8-12 week course window, not a single-visit transformation.
            Who performs salmon DNA injections at a Seoul clinic — and does it matter?
            Kind Global Clinic Myeongdong's salmon DNA injections are performed personally by 2 licensed Korean co-directors — Dr. Lee Wonjin (KR Medical License 143124, Daegu Catholic University College of Medicine, 2022) or Dr. Lee Kangin (KR Medical License 141247) — with a 15-20 minute consultation, zero nurse delegation, and same-physician continuity from consultation through the month-6 follow-up. It matters because dosing across a multi-session course is a judgment call: the physician who saw your baseline calibrates session two and three. At volume clinics, injectable skin boosters are among the most commonly delegated treatments, and a different injector per visit breaks exactly that calibration.
            How much do salmon DNA injections cost in Seoul, Korea?
            ₩149,000 (≈ $106) is the published entry point for a PN session (Rejuran HB 1cc) at Kind Global Clinic Myeongdong, with Healer 2cc at ₩179,000 (≈ $128), Eye 1cc at ₩119,000 (≈ $85), the 4cc Signature at ₩249,000 (≈ $178), a first-visit 2cc rate of ₩169,000 (≈ $121), and targeted PDRN at ₩100,000 (≈ $71) per 1cc. Seoul pricing generally runs 50-80% under comparable US, UK or Singapore quotes for the same injectable class — Korea is where the products are manufactured. The full tier-by-tier breakdown lives on the salmon sperm facial price page, and every figure is identical for international and Korean patients.
            Salmon DNA injection vs HA filler — what is the difference?
            Different molecules doing different jobs, and neither substitutes for the other.
            AxisSalmon DNA (PN/PDRN)HA filler
            MoleculeDNA fragmentsHyaluronic acid gel
            ActionSignals repair — texture, elasticity, fine linesAdds physical volume — folds, cheeks, lips
            Result timingBuilds over an 8-12 week courseImmediate on the table
            DurationMaintenance session in the 6-12 month rangeProduct-dependent, typically 6-18 months
            In a Korean randomized split-face trial in the periocular zone, PN was tested directly against HA and delivered measurable rejuvenation — which is why thin under-eye skin, where filler carries the most risk, is where PN earns its place first.
            Are salmon DNA injections safe? What are the side effects?
            The published safety profile is favorable: after purification, salmon DNA is highly biocompatible with human tissue and provokes minimal immune response, which is a core reason this source material was chosen for regenerative products in the first place. Expected effects are visible micro-injection marks, small bumps and mild swelling for 24-48 hours, with possible minor bruising in the under-eye zone; serious reactions are rare in the clinical literature spanning PDRN pharmacology reviews and PN cohort studies. Kind Global Clinic screens contraindications — active infection, certain autoimmune conditions, pregnancy — in the co-director consultation, and the physician who screens you performs the injection.
            How much downtime does a salmon DNA injection have?
            24-48 hours of visible micro-injection marks is the honest downtime — social rather than medical. The grid of tiny bumps flattens within a day for most patients, makeup is fine from 24 hours once the points close, and work or sightseeing the next day is routine. The under-eye zone can hold faint marks a day longer, so patients with photos or events plan sessions 2-3 days ahead. Saunas, jjimjilbang, hot yoga and alcohol stay off the schedule for 48 hours, and exfoliating acids or retinoids pause for the week. There is no wound care, no dressing and no activity restriction beyond that.
            How many sessions do I need, and how long do results last?
            3 sessions spaced 2-4 weeks apart is the standard course the published evidence pattern supports — prospective polynucleotide studies document improvement accumulating across the course rather than arriving in week one. Early hydration and smoothness typically read within 1-2 weeks of session one; the texture, fine-line and elasticity changes that justify the treatment consolidate in the 8-12 week window. After a completed course, results hold for most patients with a single maintenance session in the 6-12 month range at the published per-session rate. For the under-eye zone, the dedicated Eye protocol follows the same curve.
            Can I get a salmon DNA injection during a short trip to Seoul and fly home after?
            Yes — a single session takes one clinic visit of 60-90 minutes in Myeongdong, and there is no flight restriction afterward, so next-day departure from Korea is routine. The practical flying notes: injection marks are visible for 24-48 hours, cabin air is dry so moisturizer and SPF matter, and airport or hotel saunas wait 48 hours. For the multi-session course, travelers either complete it across return trips to Seoul at the published per-session price or take session one in Korea with a written pacing plan and messenger follow-up. Kind Global Clinic sits a 5-minute walk from Myeongdong Station Exit 6, open 7 days, with English consultation available.
            Who is a good candidate for salmon DNA skin injections?
            The profiles the literature and clinic experience support: under-eye fine lines and crepey thin skin — the zone where a Korean split-face trial tested PN head-to-head — post-acne texture and enlarged pores, dull or dehydrated skin that no longer answers to skincare, and early elasticity loss in patients from their late 20s onward who are not ready for energy devices or filler. It is also the standard regenerative pairing after resurfacing treatments. Poor candidates are those seeking volume, expecting one-session results, or with screening contraindications. The 15-20 minute consultation at Kind Global Clinic settles candidacy honestly — including telling you no when the skin says no.
            Can salmon DNA injections be combined with other treatments?
            Yes — and the combinations are where Seoul clinics use them most deliberately. Pairing PN with Potenza microneedling puts a repair signal behind a collagen-remodeling treatment, and DermaShine-assisted delivery is used for even full-face placement of skin boosters. In targeted acne-scar care, a 1cc PDRN injection supports healing alongside scar-remodeling procedures. Sequencing is a physician decision — same-day compatibility, order and intervals are set in the co-director consultation, and combination quotes are composed from the published single-treatment tiers rather than invented as bundle pricing.
            How do I know the vial actually contains genuine salmon DNA product?
            Ask to see the vial opened — at Kind Global Clinic Myeongdong that is standard: the sealed vial is opened in front of you, and the product name, volume and lot number are recorded on your chart before injection. Rejuran is a KFDA-regulated, Korean-manufactured PN product with a traceable supply chain, and 'genuine devices, genuine quantities' is a checkable process rather than a slogan. The category's celebrity fame has produced diluted and topical imitations trading on the salmon name, so the verification habit matters: a clinic confident in its sourcing shows you; a clinic that deflects the question has answered it.
            Why ask Kind Global Clinic about salmon DNA injections in Myeongdong?
            Because the explanation and the injection come from the same licensed physician. Both co-directors (KR Medical Licenses 143124 and 141247) consult and inject personally — zero delegation — from a private 1:1 suite on the 6th floor at 26 Myeongdong-gil, a 5-minute walk from Myeongdong Station Exit 6, open 7 days with no lunch-break closure. Every tier is published and identical for Korean and international patients, from the first-visit 2cc at ₩169,000 (≈ $121) upward, booking runs over WhatsApp, and the consultation carries no obligation: if PDRN, PN or neither fits your skin, that is what you will be told, in writing.
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            Get the ingredient-level answer for your own skin.

            You now know what a salmon DNA PDRN injection is — the remaining question is whether PN, PDRN or neither fits your skin, and that is a physician call. A 15-20 minute co-director consultation at Kind Global Clinic Myeongdong settles it, with published tiers from the ₩169,000 (≈ $121) first-visit 2cc rate, vial verification on your chart, and the same KRW for international and Korean patients — 7 days a week, a 5-minute walk from Myeongdong Station Exit 6.

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