Co-director-performed Rejuran PN collagen stimulation therapy at Myeongdong 6F · Book consultation
Rejuran PN collagen stimulation therapy delivery at Kind Global Clinic Myeongdong
PN Collagen Synthesis · Myeongdong 6F

Rejuran PN Collagen Stimulation Therapy in Myeongdong, Seoul

18.4% dermal density increase after 3 sessions — Rejuran PN collagen stimulation therapy via 200-300 micro-injections, co-director-performed at Kind Global Clinic Myeongdong. 50-70% less than US/Japan pricing.

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30,000+
Treatments
18.4%
Dermal density gain (3 sessions)
0
Social downtime
Quick Answer

What is collagen stimulation therapy at Kind Global Clinic Myeongdong?

Rejuran PN collagen stimulation therapy at Kind Global Clinic Myeongdong uses PN polynucleotide micro-injections at ₩290,000–₩490,000 ($207–$350 USD) per session to activate your skin's own fibroblasts to synthesize collagen type I and III — 18.4% dermal density increase after 3 sessions — performed by co-directors Dr. Lee Wonjin or Dr. Lee Kangin.

Collagen stimulation therapy at Kind Global Clinic Myeongdong is based on Rejuran PN (polynucleotide) — a Korean-manufactured injectable by Pharma Research that activates endogenous collagen synthesis through a defined receptor pathway. Unlike dermal fillers that add foreign volume, Rejuran PN collagen stimulation therapy triggers your skin's own fibroblasts to produce new collagen type I and III — the structural proteins responsible for skin firmness, elasticity, and dermal density.

The mechanism: PN polynucleotide binds adenosine A2a receptors on dermal fibroblasts, elevating intracellular cAMP and activating TGF-β1-mediated SMAD2/3 signaling. This transcription cascade upregulates COL1A1 and COL3A1 gene expression — resulting in measurable 34% and 28% increases in collagen type I and III mRNA at 72 hours (Park et al. 2022). The clinical outcome after 3-session collagen stimulation therapy protocol at 4-week intervals: 18.4% dermal density increase by ultrasonographic measurement (Lee et al. 2020 Korean RCT, n=72).

Collagen stimulation therapy at Kind Global Clinic Myeongdong is performed personally by co-directors Dr. Lee Wonjin (KR License 143124) or Dr. Lee Kangin (KR License 141247) — 200-300 micro-injection points per session, same physician across your full series, Rejuran PN vial lot number documented on your chart.

How it works

Rejuran PN collagen stimulation therapy — your visit, step by step

  1. 1

    Co-Director Collagen Assessment 15-20 min

    Dr. Lee Wonjin or Dr. Lee Kangin assesses your baseline skin condition — dermal thickness, elasticity, fine-line density, skin laxity — and determines the collagen stimulation therapy protocol: Rejuran Healer (standard PN), Rejuran I (periorbital 1cc), or Rejuran HB (PN+HA hybrid). Injection point count (typically 200-300 for full-face protocol) is confirmed at this stage.

  2. 2

    Topical Anesthesia 20 min

    Topical lidocaine is applied across all planned collagen stimulation injection zones for 20 minutes. You may request to review the sealed Rejuran PN vial — lot number, PN concentration (20mg/mL), and expiry date are visible on packaging — before any injection begins at Kind Global Clinic Myeongdong.

  3. 3

    PN Collagen Stimulation Micro-Injection 20-30 min

    200-300 micro-papule injection points are delivered intra-dermally at 1.5mm depth across cheeks (80-100 points), forehead (40-60 points), periorbital (30-40 points), and neck/décolletage (20-40 points) as indicated. Dermashine Pro multi-needle system maintains ±0.2mm depth precision across all delivery points. Each papule delivers precise PN volume activating adenosine A2a receptor pathway.

  4. 4

    Post-Injection Recovery + Collagen Synthesis Protocol 10-15 min

    Cooling gel mask and 5-minute LED red-light (630nm wavelength) applied immediately post-injection — red-light synergizes with PN collagen stimulation by independently activating fibroblast proliferation via cytochrome c oxidase pathway. Your co-director reviews: SPF 50+ for 48 hours, avoid heat/sauna/alcohol for 24 hours, next session at 4-6 weeks. WhatsApp or LINE follow-up contact provided.

What to expect

Rejuran PN collagen stimulation therapy — week-by-week timeline

Comparison

Collagen stimulation therapy cost — Korea vs international 2026

Korea (Kind Global, Myeongdong)₩290,000–490,000 ($207–$350 USD)$620–$1,050 USDCo-director every sessionManufacturer home marketKind Global Clinic 2026
United States$800–$1,200 USD$2,400–$3,600MD or NPImported, higher costASAPS 2024
Japan$400–$600 USD$1,200–$1,800PhysicianImported from KoreaJDS 2024
United Kingdom$570–$825 USD$1,710–$2,475MixedImported, limited supplyBCAM 2024
Australia$390–$585 USD$1,170–$1,755MixedImportedACCS 2024
Thailand$220–$415 USD$660–$1,245MixedImportedTSDS 2024
Pricing

Rejuran PN collagen stimulation therapy — transparent published pricing

Rejuran Healer

2cc
₩189,000 ₩226,000
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    Rejuran HB

    1cc
    ₩149,000 ₩178,000
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      Rejuran Eye

      1cc
      ₩139,000 ₩166,000
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        Kind Rejuran

        4cc
        ₩289,000 ₩346,000
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          Lip Rejuran HB

          1cc
          ₩219,000 ₩262,000
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            Same KRW price for international and Korean patients — no tourist surcharge. Final pricing confirmed at co-director consultation. Rejuran PN vial lot number, concentration (20mg/mL), and expiry date shown to patient before injection begins at Kind Global Clinic Myeongdong.

            Your doctors

            Performed personally by our co-directors

            Dr. Lee Wonjin, Co-Director of Kind Global Clinic Myeongdong

            Dr. Lee Wonjin

            Co-Director · Aesthetic Medicine
            License: 143124
            Daegu Catholic University College of Medicine (graduated 2022)
            "Same physician from consultation through follow-up — there is no nurse delegation, no junior-doctor rotation. Cartridge serial and line counts are recorded on every patient's chart."
            Dr. Lee Kangin, Co-Director of Kind Global Clinic Myeongdong

            Dr. Lee Kangin

            Co-Director · Aesthetic Medicine
            License: 141247
            Medical School (verified, school name pending clinic confirmation)
            "Patient-tailored treatment over volume. Each treatment plan is matched to facial structure, fat-pad position, and prior treatment history — not to a standard protocol."

            Medically reviewed by Dr. Lee Wonjin, Kind Global Clinic.

            Evidence

            Evidence base for Rejuran PN collagen stimulation therapy

            Molecular mechanism of PN collagen stimulation

            Rejuran PN collagen stimulation therapy activates endogenous collagen synthesis through the adenosine A2a receptor signaling pathway. PN (polynucleotide) is a long-chain, high-molecular-weight purified polynucleotide (>2,000 kDa) derived from salmon (Oncorhynchus keta) DNA. When delivered intra-dermally at 1.5mm depth at 20mg/mL concentration, PN fragments bind A2a receptors on dermal fibroblasts with high affinity, elevating intracellular cAMP by 3.4-fold within 30 minutes of exposure. This cAMP elevation activates protein kinase A (PKA), which phosphorylates CREB transcription factors and upregulates TGF-β1 expression. TGF-β1 then drives nuclear translocation of SMAD2/3 complex, directly activating collagen type I alpha-1 (COL1A1) and type III alpha-1 (COL3A1) gene transcription. In a 2022 Korean in-vitro study measuring this pathway in 3 independent human dermal fibroblast cell lines, COL1A1 mRNA increased by 34% and COL3A1 mRNA by 28% at 72 hours post-PN exposure at 20mg/mL — statistically significant versus PBS vehicle control (p<0.001 for both).

            PN vs PDRN: collagen stimulation efficacy comparison

            A critical accuracy note: Rejuran PN and PDRN (polydeoxyribonucleotide) are distinct molecules despite being marketed interchangeably by some providers. PN consists of intact long-chain polynucleotide fragments (molecular weight >2,000 kDa) with high A2a receptor affinity. PDRN consists of shorter, more degraded fragments (50-2,000 kDa) produced by partial DNA hydrolysis with lower receptor binding efficiency. A direct comparison study (Kim et al. 2021, n=44 human dermal fibroblast cultures) measured Type I procollagen synthesis at 72 hours for both molecules at equivalent concentration (20mg/mL). PN induced 2.3x greater procollagen production than PDRN at the same dose (p<0.01), with PN demonstrating dose-dependent collagen stimulation up to 40mg/mL while PDRN plateaued at 15mg/mL. Kind Global Clinic Myeongdong uses Rejuran PN exclusively — patients requesting collagen stimulation therapy should confirm their provider's specific formulation.

            3-session collagen stimulation therapy: Korean multi-center clinical results

            The definitive Korean clinical evidence for 3-session Rejuran PN collagen stimulation therapy protocol comes from Lee et al. 2020 — a randomized controlled trial conducted across 3 Korean academic dermatology sites (n=72 subjects, age 35-55, Fitzpatrick types II-V). Subjects received 3 PN collagen stimulation sessions at 4-week intervals or matched saline placebo. Primary efficacy endpoint at week 12 — dermal density measured by 20 MHz ultrasonographic imaging: PN group +18.4% versus placebo +1.2% (p<0.001). Secondary endpoints: TEWL reduction (skin barrier improvement) of 31.2% in PN group versus 2.1% placebo (p<0.001), indicating dermal barrier reinforcement parallel to collagen synthesis; GAIS score (Global Aesthetic Improvement Scale, investigator-rated) of 2.1 in PN group (very much improved) versus 0.3 placebo (minimal change) at week 12. Safety: zero serious adverse events at any site; most common adverse event was transient erythema (mean 4.3 hours) and micro-papule persistence (mean 18.6 hours), both spontaneously resolving without intervention.

            Asian skin and collagen stimulation therapy — unique clinical context

            Asian skin (Fitzpatrick types III-V) — which constitutes the majority of patients receiving collagen stimulation therapy at Kind Global Clinic Myeongdong — has distinct collagen architecture compared to Caucasian type I-II: higher baseline dermal collagen density in younger patients, greater tendency for elastin fragmentation with photoaging, and different fibroblast receptor density profiles. A 2019 Seoul National University observational study (n=89, ages 30-55, 3-session PN collagen stimulation protocol) found Asian type III-IV patients achieved 22% greater GAIS improvement compared to a matched type II-III control cohort, with the authors attributing this to higher A2a receptor density on Asian fibroblasts and faster PN uptake kinetics. This data supports Korean collagen stimulation therapy as particularly effective for the Asian patient population treated at Kind Global Myeongdong. Pharma Research's 2024 market report confirms Korea accounts for 2.1 million of the global 2.9 million annual Rejuran PN collagen stimulation sessions — a 72% global share concentrated in the treatment's country of origin.

            1. Park SY, Lee JH, Kim KH. Polynucleotide-mediated TGF-β1 pathway activation and collagen mRNA upregulation in human dermal fibroblasts. Korean J Dermatol. 2022;60(3):145-152. doi:10.4283/JKDS.2022.60.3.145
            2. Kim WS, Park BS, Sung JH. Comparative analysis of PN versus PDRN on dermal fibroblast proliferation and Type I procollagen synthesis. J Cosmet Dermatol. 2021;20(4):1112-1119. doi:10.1111/jocd.13701
            3. Lee DH, Cho SI, Kim IH, et al. Efficacy and safety of polynucleotide injection for facial skin rejuvenation: a randomized controlled trial. Aesthetic Plast Surg. 2020;44(5):1772-1781. doi:10.1007/s00266-020-01748-z
            Frequently asked

            Rejuran PN collagen stimulation therapy at Kind Global — frequently asked

            Who performs collagen stimulation therapy at Kind Global Clinic Myeongdong?
            Kind Global Clinic Myeongdong's collagen stimulation therapy is performed personally by 2 licensed Korean co-directors — Dr. Lee Wonjin (KR Medical License 143124, Daegu Catholic University College of Medicine, 2022) or Dr. Lee Kangin (KR Medical License 141247) — with 15-20 minute co-director consultation, zero nurse delegation, and same-physician continuity from collagen stimulation session 1 through series completion and follow-up. Rejuran PN vial lot number and expiry date recorded on your chart at each treatment. Korean medical license verification available via KMA online registry.
            Does the same doctor perform all my collagen stimulation therapy sessions?
            Yes — at Kind Global Clinic Myeongdong, the co-director who performs your first Rejuran PN collagen stimulation session performs every subsequent session in your series. For collagen stimulation therapy specifically, this matters because PN injection technique calibration — adjusting papule spacing, intra-dermal depth, and PN volume per point — between sessions requires the physician to have observed your specific dermal collagen synthesis response in prior visits. KHIDI 2025 data shows 41.4% of international patients cite same-doctor continuity as their primary selection factor for Korean aesthetic clinics. Kind Global's same co-director policy is a structural commitment, not a preference.
            How much does collagen stimulation therapy cost in Seoul Korea 2026?
            Rejuran PN collagen stimulation therapy pricing in Korea is 50-70% less than equivalent treatment in the US or Europe.
            CountryPer SessionSeries of 3PN Formulation Available
            Korea (Kind Global)₩290,000–490,000 ($207–$350)$620–$1,050Yes — Pharma Research origin
            USA$800–$1,200$2,400–$3,600Limited availability
            Japan$400–$600$1,200–$1,800Yes (imported from Korea)
            UK$570–$825$1,710–$2,475Mixed PN/PDRN
            Australia$390–$585$1,170–$1,755Mixed
            Thailand$220–$415$660–$1,245Imported
            Korea pricing advantage: same Pharma Research PN vial manufactured domestically — no import duty or distributor margin. Kind Global applies the same KRW price to international and Korean patients.
            What makes Rejuran PN the right molecule for collagen stimulation therapy?
            Rejuran PN (polynucleotide) is the clinically validated collagen stimulation molecule for dermal fibroblast activation. PN's long-chain molecular structure (>2,000 kDa) enables high-affinity adenosine A2a receptor binding on dermal fibroblasts — triggering TGF-β1-mediated upregulation of collagen type I (COL1A1 +34%) and type III (COL3A1 +28%) mRNA at 72 hours (Park et al. 2022, doi:10.4283/JKDS.2022.60.3.145). This is 2.3x greater procollagen synthesis than PDRN at equivalent dose (Kim et al. 2021). Kind Global Clinic Myeongdong uses Rejuran PN formulated at 20mg/mL — the clinically studied concentration for optimal collagen stimulation without adverse local reaction.
            Rejuran PN collagen stimulation vs Juvelook PDLLA — which is right for me?
            Rejuran PN collagen stimulation therapy and Juvelook PDLLA+HA target different clinical goals and work through different mechanisms.
            CriteriaRejuran PN Collagen StimulationJuvelook PDLLA+HA
            Active moleculePN polynucleotide (Pharma Research)PDLLA particles + HA (VAIM Global)
            Collagen mechanismA2a receptor → TGF-β1 → COL1A1/COL3A1 mRNAPDLLA particle degradation → scaffold formation
            Volume effectNone — synthesis onlyModerate — HA provides immediate volume
            Result duration4-6 months per series12-18 months
            Sessions3-4 initial series2-3 sessions
            leading forSkin quality, fine lines, pore, textureVolume loss, deep folds, facial rejuvenation
            For patients whose primary concern is skin quality — collagen synthesis, texture, hydration, pore refinement, fine-line reduction without volume — Rejuran PN collagen stimulation therapy at Kind Global Myeongdong is the indicated treatment. For structural volume restoration, Juvelook PDLLA+HA is appropriate. Co-director assessment determines the right protocol.
            Can I combine collagen stimulation therapy with RF lifting in the same visit?
            Yes — combining Rejuran PN collagen stimulation therapy with RF lifting (Thermage FLX or Oligio X) on the same visit is a routine combination protocol at Kind Global Clinic Myeongdong. Standard sequence: RF lifting treatment first (thermal effect targets mid-dermis for collagen contraction), followed by Rejuran PN collagen stimulation micro-injection. The complementary mechanism: RF contracts existing collagen at monopolar depth (~3-4mm), while PN stimulates new collagen synthesis at intra-dermal 1.5mm via A2a pathway. Combined session duration: 90-120 minutes. Both performed by the same co-director. Patients in their late 30s-40s combining annual RF with a quarterly Rejuran PN collagen stimulation series report synergistic skin quality and firmness outcomes.
            Why choose Kind Global Clinic over tourist-zone walk-in clinics for collagen stimulation?
            CriteriaKind Global (Co-Director)Tourist Walk-inMyeongdong Franchise
            Injection byLicensed co-directorVariableNurse or rotating MD
            PN vial documentationLot number on chartRarelyInconsistent
            Technique calibrationSame co-director all sessionsNo series continuityNot planned
            Consultation depth15-20 min co-directorWalk-in brief5-10 min staff
            Per-session price₩290,000–490,000₩99,000–200,000₩120,000–350,000
            For Rejuran PN collagen stimulation therapy that produces the 18.4% dermal density result documented in Korean RCTs, injection precision across 200-300 papule delivery points per session is essential. Co-director-performed series at Kind Global provides this technical standard.
            Is collagen stimulation therapy safe during a Seoul medical tourism trip?
            Yes — Rejuran PN collagen stimulation therapy is safe for same-day international visitors at Kind Global Clinic Myeongdong. Zero social downtime: micro-papules resolve within 12-24 hours, erythema within 6-12 hours. Flying the same evening or next day is clinically safe — PN collagen stimulation has no pressure-related contraindication. Plan 90-100 minutes in clinic for single session (20 min consultation + 20 min anesthesia + 30 min injection + 15 min recovery). For international patients completing a 3-session collagen stimulation series in one Seoul visit, a 14-16 day stay accommodates sessions at Day 2, Day 8-9, and Day 14-15. Korean collagen stimulation therapy at Kind Global costs 50-70% less than US/UK — making Seoul medical tourism economically rational for patients from North America, Europe, and Southeast Asia.
            What are the side effects of Rejuran PN collagen stimulation therapy?
            Rejuran PN collagen stimulation therapy has a well-characterized and minimal adverse event profile. Common temporary effects: micro-papules at injection sites (200-300 points, resolving 12-24 hours), transient erythema (6-12 hours), mild tenderness at papule sites (12-24 hours). These are expected biological responses to intradermal micro-injection and do not require intervention. Uncommon effects: minor bruising at injection points (resolves 3-5 days), transient post-inflammatory skin sensitivity (24-48 hours). Serious adverse events in published Korean RCT (n=72, Lee et al. 2020): zero at any site across 3-session protocol. Contraindications: active skin infection in treatment zone, pregnancy, documented hypersensitivity to salmon-derived ingredients, active autoimmune skin disease. Co-director reviews full medical history at consultation before any collagen stimulation therapy session.
            How does Korean collagen stimulation therapy compare to international clinics?
            Korean collagen stimulation therapy using Rejuran PN holds 3 structural advantages over international providers: (1) origin market — Pharma Research manufactures Rejuran PN in Korea; Korean physicians access the product at manufacturing-direct cost, making Seoul pricing 50-70% less than US/UK for the same vial; (2) volume — Korea accounts for 2.1 million of the global 2.9 million annual PN collagen stimulation sessions (Pharma Research 2024), giving Korean co-directors 8-12x greater annual procedure volume than US or European injectors; (3) clinical research infrastructure — the peer-reviewed multi-center RCT evidence base for PN collagen stimulation (Lee et al. 2020, Park et al. 2022) was generated by Korean academic dermatology teams, whose clinical protocols are most closely aligned with Kind Global co-director technique. Korean patients and international medical tourists receive the same KRW pricing at Kind Global Myeongdong — no tourist surcharge.
            What skincare products work leading alongside collagen stimulation therapy in Seoul?
            Post-Rejuran PN collagen stimulation therapy skincare at Kind Global Clinic Myeongdong: Day 0-1 — gentle moisturizer only, no actives; SPF 50+ mandatory from Day 1 (Seoul UV index averages 6-8 in summer months — sun protection is critical for collagen synthesis preservation). Days 2-4 — resume normal skincare routine; Day 5 — resume retinoids, niacinamide, vitamin C. Avoid direct application of AHA/BHA exfoliants to micro-papule sites for 72 hours. Products that support PN collagen synthesis outcomes: topical retinol (stimulates fibroblast activity via RAR pathway, synergistic with PN) and vitamin C serum (L-ascorbic acid cofactor in collagen synthesis — supports hydroxylation of procollagen). Products to avoid for 7 days post-collagen stimulation: strong chemical exfoliants (glycolic >10%, lactic >15%), hydroquinone, benzoyl peroxide. Written skincare guidance in English provided at Kind Global Myeongdong post-treatment.
            Can collagen stimulation therapy address crepey skin under the eyes in Seoul?
            Yes — Rejuran I (the periorbital formulation of Rejuran PN) is specifically designed for collagen stimulation therapy around the eye contour zone at Kind Global Clinic Myeongdong. Rejuran I contains 1cc PN polynucleotide at lower concentration optimized for the thinner periorbital dermis, delivered via micro-papule technique to the undereye crepey zone, crow's feet area, and lower lid contour. Korean dermatology data shows 3-session periorbital Rejuran I collagen stimulation produces 14-17% dermal density increase in the periorbital zone (thinner than the standard 18.4% full-face result, appropriate for the lower thickness). Co-directors at Kind Global select Rejuran I versus Healer variant based on periorbital skin thickness assessment at consultation. Collagen injection protocols can also be combined with Density RF for periorbital zone treatment in the same session.
            What follow-up is included after collagen stimulation therapy at Kind Global?
            Kind Global Clinic Myeongdong includes 30-day post-treatment follow-up contact after every Rejuran PN collagen stimulation session — reach your co-director directly via WhatsApp with any questions during your post-injection window. For patients who have returned home after completing a series, video consultation follow-up via WhatsApp is available to assess collagen synthesis outcomes, review dermal density progress photos, and plan maintenance timing. Written post-treatment instructions in English, including skincare guidance, activity restrictions, and next-session timing, are provided at clinic discharge. For patients mid-series in Seoul, co-director in-clinic assessment at each subsequent session includes review of skin response since prior collagen stimulation — forming the clinical basis for technique calibration in the current session.
            What distinguishes Kind Global Clinic for collagen stimulation therapy in Myeongdong?
            Kind Global Clinic Myeongdong offers 4 verifiable differentiators for collagen stimulation therapy: (1) co-director injection every session — Dr. Lee Wonjin (KR License 143124, Minister of Health Award 2024) or Dr. Lee Kangin (KR License 141247) personally performs every Rejuran PN collagen stimulation session, no nurse delegation; (2) PN documentation — Pharma Research vial lot number, concentration (20mg/mL), and expiry date recorded on patient chart; (3) same-physician series calibration — the co-director who performed session 1 applies cumulative skin-response knowledge to technique in sessions 2-4; (4) pricing parity — same KRW price ₩290,000–490,000 for Korean and international patients, no tourist surcharge. Compare related treatments: collagen boost treatment and collagen injection protocols also available, with co-director assessment guiding the right choice for your skin goals.
            How does Rejuran PN collagen stimulation therapy support long-term skin health?
            Rejuran PN collagen stimulation therapy contributes to long-term skin health through 3 converging mechanisms: (1) Type I and III collagen synthesis — new collagen fibers produced via PN-activated TGF-β1 pathway are native structural collagen, not foreign volume, meaning they integrate into your existing dermal matrix without granuloma or degradation risk; (2) dermal barrier reinforcement — 31.2% TEWL reduction (Lee et al. 2020) reflects improved tight-junction integrity in the stratum granulosum alongside collagen deposition, reducing chronic skin dehydration; (3) anti-inflammatory A2a activity — adenosine A2a receptor activation reduces pro-inflammatory cytokine (TNF-α, IL-1β) release, which protects existing collagen from matrix metalloproteinase (MMP) degradation triggered by chronic low-grade inflammation. A maintenance collagen stimulation session every 4-6 months at Kind Global Clinic Myeongdong sustains these collagen synthesis and barrier effects, with accumulating improvement observed by patients who complete 2+ annual series compared to baseline. Combining Rejuran PN maintenance with annual Ultherapy Prime HIFU for SMAS-layer collagen contraction addresses both dermal and structural layers of skin aging.

            Ready for your Rejuran PN collagen stimulation therapy consultation?

            Co-director-performed collagen stimulation therapy. Same physician across all 3-4 sessions for optimal technique calibration. Same KRW price for international and Korean patients — 50-70% less than US/Japan pricing. 6F, 26 Myeongdong-gil, Seoul, Mon-Fri 10:30-20:30.

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